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Zhang J, Ye J, Altafaj A, Cardona M, Bahi N, Llovera M, et al

For example, oxidative or electrophilic modification of specific cysteine residues (i.e., C151) on KEAP1 causes a conformational change in the KEAP1-CUL3-RBX1-NRF2 complex that prevents NRF2 ubiquitylation and degradation (912)