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Phenomenex) coupled to an Agilent 6546 LC/Q-TOF system with a Dual AJS ESI source operated in positive ion mode

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In the presence of GSH, GPX4 continuously reduce PLOOHs, and if GSH depletion or GPX4 inactivation, intracellular ferrous ions induce ferroptosis by breaking down PLOOHs to cause lipid peroxidation (Ursini and Maiorino, 2020)

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha