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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

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Importantly, not all tumours rely on new blood vessel formation to survive and grow [47], and therefore the angiogenic switch might never occur

Furthermore, elevated lactate concentrations were tentatively linked to the mitigation of pyruvate dehydrogenase (PDH) activity