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Here, we benchmarked several engineered laccase templates 22,23,24,25 , identified an ancestral fungal variant with slight activity in HEK293T cells and performed extensive directed evolution on the yeast surface to improve its activity (Fig

Silagen is typically applied twice daily for 8-12 weeks, or longer for more severe scars

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Immunohistochemical findings Immunostaining for CD68 and F4/80 was used to assess the early inflammatory response, specifically focusing on macrophage presence within the grafts