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Internal factors: DNA repair, diseases, activation of the immune system, excessive use of glutathione due to reasons such as overexposure to toxic substances, which occur in our body, is related to the increased need for glutathione

Although strategies such as iron chelators (e.g., deferoxamine), antioxidants (e.g., N-acetylcysteine), and GPX4 activation demonstrate neuroprotective potential in animal and cellular models, their safety, tolerability, blood-brain barrier permeability, and ability to modulate disease progression in humans have not been systematically validated

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250,251 At the same time, ethanol can directly affect the activities of MAT, BHMT, and other enzymes, interfere with Met metabolism, inhibit GSH formation, and weaken the antioxidant capacity of cells