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These include genes encoding antioxidants, cell rescue/defense proteins, and signaling proteins such as kinase, phosphatase, and transcription factors

In summary, methionine restriction selectively exacerbates the oxidative stress in cancer cells by targeting their antioxidant metabolic vulnerability-particularly through disrupting glutathione synthesis-thereby ultimately inducing cell death

332(6026):243247 Moyat M, Coakley G, Harris NL (2019) The interplay of type 2 immunity, helminth infection and the microbiota in regulating metabolism

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice