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Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

K.ZhengY

We can confirm that the first rate-limiting enzyme of GSH synthesis, the GCS is essential for protection (0% survival rate of gcs(RNAi)- worms under the given arsenite concentration) ( Figure 1b )

The D-amino acid substitutions and the C-terminal amide protect the peptide from enzymatic degradation, providing research half-life in the range of 15-60 minutes depending on administration route