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The human DRD2 gene encoding the D 2 R is highly polymorphic

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This longevity of research interest is itself informative: compounds that fail to replicate across independent laboratories typically disappear from the literature within a decade

Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions