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Excess -KG from IDH2 mutations and GLU metabolism is also shuttled into the cytosol via SLC 25A11, where hypoxic and acidic conditions further elevate 2HG levels (148)

doi: 10.53858/arocpb05020117 24

Abnormal sphingolipid metabolism can lead to the occurrence of PD by inducing insulin resistance [177]

We next used BODIPY-C11 (a lipid-soluble ratiometric fluorescent indicator of lipid peroxidation) to estimate the level of ferroptosis-associated lipid peroxidation in ERO1 knockout or knockdown cells