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Moreover, Sal B exhibits bidirectional regulation of lactyl-modifying enzymes: it inhibits p300/CBP lactyl transferase activity while enhancing HDAC3's de-lactylation function, thereby synergistically restoring dynamic equilibrium in histone lactylation [60]

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Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy

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