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Interestingly, in contrast to ChEIs, memantine, which antagonizes NMDA receptors, attenuated antipsychotic-induced EPS ( Figure 6 )

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Moreover, autophagy inhibitors ( e.g., bafilomycin A1 and chloroquine) or knockout of autophagy-related gene 3 (ATG3) and ATG13, two core contributors to autophagy, reduced cell sensitivity to ferroptosis[66]

The proposed mechanism involves preventing GABA receptor downregulation, counteracting compensatory NMDA receptor sensitization, and stabilizing benzodiazepine receptor configuration