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It activated the Nrf-2/ARE signaling pathway, this subsequently decreased the elevated production of ROS and MDA, enhanced the expression of SOD and GSH, and ultimately resulted in a reduction of oxidative stress levels

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The aberrant activation of Nrf2 in cancer cells leads to increased expression of Glucose-6-phosphate dehydrogenase (G6PD), transketolase (TKT), 6-phosphogluconate dehydrogenase (PGD), and other metabolic enzymes promoting glutamine and glucose metabolism in pentose phosphate pathway (PPP) and increasing synthesis of amino acids participating in metabolic reprogramming required for cell proliferation (Mitsuishi et al