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This is thought to be due to TNF--induced hepatocyte apoptosis and can be rescued by combined loss of TNF (i.e., TBK1 / TNF / mice are viable) ( High levels IFN- or induction of IFN-stimulated genes (i.e., the IFN signature) is a remarkably consistent feature of SLE and is associated with high titers of affinity-matured autoantibodies and worse disease outcome ( IFN-Is in Protective and Pathogenic Immune Responses Among members of the IFN-I family in humans and mice, IFN- and IFN- are the best characterized and most broadly expressed

The results of in vivo experiments showed that the motor function of the rats was restored and that the gel scaffold effectively reduced glial scar formation, lesion size, and cyst area (Long et al., 2020)