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Description

Our findings suggest that change in pH allows alterations in native states of Prdx6 at pH 7.0 and 4.0 such that the changes make the protein resistant to thermal denaturation at low pH

Non-selective COX inhibitors can result in many adverse effects, such as gastrointestinal complications and renal toxicity, mainly because COX inhibitors disturb the balance of anti-thrombotic prostacyclins (PGI 2 ) and pro-thrombotic thromboxane A2 (TXA 2 ) production (Bresalier et al., 2007)