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Conclusions In summary, Schwann-like cells converted from GMSCs retained potent immunomodulatory functions to promote pro-regenerative (M2) macrophage polarization and suppress pro-inflammatory (M1) macrophage activation

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Intriguingly, under cystine-deprived conditions, the GCL complex catalyzes -glutamyl-peptides accumulation instead 11

FIGURE 4 Potential Links Between LOX and Aging-Associated Cartilage Degeneration Aging, which is characterized by a chronic and low-grade inflammation, also termed as age-associated inflammation, which has been referred to as inflamm-aging (Huang et al., 2019