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To test whether replacing S 213 by an acidic residue could lure GSK3 by mimicking phosphorylation, we produced and purified the C STD3 S 213 E mutant

The optimal synthesis parameters were found to be a precursor solution consisting of 2.5 g citric acid and 1000 L ethylenediamine in water under 5 min microwave irradiation to produce CDs capable of detecting NO with a 4.6 M LOD