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The work of Zhang and colleagues demonstrated the accumulation of intracellular ROS and the subsequent activation of the NLRP3 inflammasome in macrophages from mice of the J774.1 line when the P2X7 receptor was activated (Zhang et al., 2021)

S623 Treatment satisfaction and quality of life in patients with irritable bowel syndrome with constipation and chronic idiopathic constipation

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Evidence For Excessive Glutamate in Chronic Fatigue Syndrome Links with Other Disorders In addition to an inflammatory milieu, oxidative stress and mitochondrial dysfunction (all of which interact), diabetes is a final condition not discussed as yet (and for which no research has been conducted on sensory gating) but which may hold a clue to glutamate as a key driver involved in ME/CFS and other neuroinflammatory conditions