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doi: 10.1038/s41598-021-81949-3 50 KeX.PanZ.DuH.ShenY.ShenJ

Dogs taking the supplement, which provided 225 mg of SAMe and 82 mg of silybin-phosphatidylcholine complex (24 mg of silybin) per day, throughout chemotherapy were less likely to exhibit increased biomarkers of liver damage and were less likely to have their chemotherapy treatments delayed due to increased liver enzyme activity

That is why it is typically given as a daily injection, often at night to mirror natural growth-hormone rhythm

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification