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The medication's stimulatory effect on metabolism may also increase baseline energy levels, making it harder to reach restful sleep in the first few days or weeks of treatment

The 12mg group may have had different baseline compositions, or the additional weight loss at 12mg may have included a slightly higher proportion of lean tissue

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Its compact molecular architecture enables selective binding to the NNMT active site, allowing researchers to study dose-dependent enzyme inhibition in vitro and in preclinical models