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Although stress is also a factor which may influence insulin resistance, no doctor treating individuals with diabetes would consider that those needing higher doses of insulin are mentally unstable, making up their disease, or suffering from the placebo effect

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Together, these data suggest that in most CRPC subtypes, AR directly binds and represses the BCL-2 locus in a ligand-dependent manner and inhibition of AR signaling would block AR occupancy at key regulatory regions such as ARBS1 allowing for transcriptional activation of BCL-2