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In addition to VQ-free compound, we also performed DMS-MaPseq using Rbs-VQ (SMe), which has low modification reactivity, to account for potential effects of the VQ moiety itself

For example, the mitochondria is a major source for ROS in both types of diabetes (151, 165)

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Elevations in serum enzyme levels are taken as the relevant indicators of liver toxicity whereas increases in both total and conjugated bilirubin levels are measures of overall liver function