inhibitor glutathione peroxidase Frontiers Thioredoxin and glutathione peroxidase (GPx)

It is important to note that rare side effects can occur with NO supplementation such as headache, nausea, diarrhea, stomach pain, and heat-palpitations and may cause low blood pressure (hypotension), methemoglobinemia (a rare blood disorder where the blood can't carry oxygen effectively), decreased platelet aggregation (increased bleeding risk), pulmonary inflammation due to the formation of nitrogen dioxide, surfactant dysfunction, and potential for toxicity in sensitive individuals, particularly newborns with certain heart conditions

For example, EGCG has been used in treating sodium nitroprusside (SNP) and ultraviolet radiation b (UVB) induced skin damage and psoriasis by regulating inflammation, apoptosis, and oxidative stress (13)

Five impact areas are identified: glycemic profile, inflammation, oxidative stress, lipid profile, and hormonal profile, each linked to metabolic and endocrine alterations characteristic of PCOS

furthermore, they require specific concentrations and careful formulation design for optimal results (22)