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Guo Z, Yan M, Chen L, Fang P, Li Z, Wan Z, et al

doi: 10.1002/jcsm.12283 355 LeeJKShinJHGwagBJChoiEJ

Mechanistically, ADP-ribosyl-transferase 2 (ART2) transfers the ADP-ribose moiety from NAD + to the neighbouring cell surface purinergic P2 7 receptor (P2 7R), thereby initiating the apoptotic programme, characterized by deregulated calcium flux, pore formation, phosphatidylserine exposure, shedding of CD62L and cell shrinkage, and hence inducing cell death in peripheral T cells exposed to NAD + [103]