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Disulfide linkers can be used to directly link therapeutic agents to the nanogel framework [109] or to crosslink the polymeric backbones, which is more common [64,98,99,100,101,102,103,104,105,106,107,108]

It is essential for maintaining the central nervous system and helps produce healthy red blood cells, which are crucial for delivering oxygen throughout the body

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2.2.4 ROS and antioxidant defense mechanisms In OA, patients, the levels of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) are significantly reduced (Ostalowska et al., 2006