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Supplementary material The Supplementary Material for this article can be found online at: References 1 AltintasO.Ozgen AltintasM.KumasM.AsilT

H358 matrix was additionally normalized by median centering prior statistical analysis

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These microenvironmental constraints can limit iron availability, activating adaptive pathways such as HIF-1, which promotes metabolic adaptation and tumor invasiveness ( Due to their rapid growth and proliferation, tumor cells have an increased demand for iron, disrupting iron metabolism