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242,244 A large population study of more than 20,000 adults ranging from 4079 years of age followed the individuals for an average of 9.5 years and found that those in the top quartile of baseline plasma vitamin C concentration had a 42% lower risk of stroke than those in the bottom quartile

In a pilot trial of NAD+ intravenous infusion in healthy adults, subjects receiving 750 mg of NAD+ over 6 hours reported no negative symptoms, and there were no vital sign abnormalities or serious laboratory derangements compared to placebo

The absence of leg cramps from official labeling does not definitively rule out a connection, as post-marketing experience sometimes reveals adverse effects not detected in pre-approval trials due to sample size limitations, duration of follow-up, or patient population differences