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Key sites include the liver, adipose tissue, lactating mammary glands, adrenal cortex, and red blood cells, which require NADPH to preserve membrane integrity.

Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens ( via alterations in the androgenic action on SCN circuitry and circadian rhythmicity

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He also discusses Neuralinks efforts to create novel brain-machine interfaces (BMI) that enhance human learning, cognition and communication as a means to accelerate human progress