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1 In addition, anti-inflammatory pathways are favored and endothelial cells produce nitric oxide, which helps keep blood vessels dilated and inhibits platelet adhesion

We used the force field parameters for single-protonated phosphorylated Ser (S1P) and Thr (T1P) residues developed by Sticht and co-workers 59

Review supplementation If elevated B12 results from excessive supplementation: Discontinue or reduce high-dose supplements unless medically indicated For patients receiving therapeutic B12 injections for confirmed deficiency, continue treatment as prescribedelevated levels are expected after replacement therapy and do not indicate toxicity Review with GP to ensure supplementation remains appropriate 3