glutathione depletion low homocysteine N-Acetyl-Cysteine supplementation lowers high plasma levels and increases synthesis in the trans-sulfuration pathway Glutathione Metabolism - an overview

There is increasing evidence showing that alteration in the concentration and subcellular distribution of NAD(P)H affects disease development and progression in aging, diabetes, Alzheimers disease and cancer

Also, inulin improves anxiety- and depression-like behaviors in alcohol-dependent withdrawal mice by increasing the number of Faecalibacterium and Roseburia , boosting the generation of SCFAs, and regulating serotonin metabolism (162)

It can enhance the expression of Piwi-like RNA-mediated gene silencing 2, which in turn activates purine metabolism to repair the damage caused by ionizing radiation [165]

Collectively, these insights support the therapeutic potential of SIN-based nano-delivery platforms targeting the bonebrain axis in the treatment of cerebral ischemia