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Consequently, the lesions induced in rats share a considerably high degree of similarity with corresponding lesions in human patients

SLC7A11 is the primary transporter protein, highly specific for cystine and glutamate, while SLC3A2 is a chaperone

Furthermore, the apoptosis of SGNs detected by C-CASP3 immunostaining and western blot showed that there was much less C-CASP3-positive SGNs and remarkable reduction of the C-CASP3 protein levels in the NAC co-treated groups compared with the peroxynitrite-only groups, and it was also lower in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figures 7B,C)

However, the method of commencement and need for additional protection varies in each case and medical consultation is advised before changing over