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Most people with mild symptoms as opposed to very mild symptoms were already unable to live independently at baseline, so for them the more relevant measure was how much longer they would be able to care for themselves

129 , 130 Practically, hypoxia not only facilitates the proliferation, migration and invasion of HCC cells, but also hastens malignant progression by affecting the crosstalk between stromal cells, tumour cells and immune cells in the TME

The limitations of this study include that the experimental findings were primarily derived from a rat model of acute myocardial ischemia, which may not fully replicate the pathophysiological complexity of human cardiovascular disease, potentially restricting the direct clinical translatability of the results

LDN, on the other hand, is often used for a longer duration