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Description

According to the 2021 HF guidelines of the European Society of Cardiology (ESC), the most effective strategy for sarcopenia treatment is resistance exercise training, possibly combined with a protein intake of 11.5 g/kg/day [1]

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The exogenous pathway consists of the activation of cell membrane transporters for transferrin (TF) and lactoferrin (LF) or the inhibition of cystine/glutamate (CySS/Glu) antiporters, while the endogenous pathway is the inhibition of GPX4 activation within cells (Li J