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242 Plasma methionine levels are significantly elevated in MAT1A knockout mice, while hepatic SAM and glutathione levels are notably decreased, with no change in SAH levels

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Consequently, this structural preservation effectively limits the infiltration of peripheral immune cells, such as T-cells and neutrophils, into the brain parenchyma, thereby significantly attenuating downstream neuroinflammatory responses (Jayanti et al., 2022