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The activation of ATF4 has a protective effect against the progression from steatohepatitis to HCC [213]

The preclinical studies have shown promising results in animal models, where NP-mediated delivery of BDNF has led to neuroprotective effects (182)

Can J Fish Aquat Sci 50(12):26672677 Ramirez AJ, Brain RA, Usenko S, Mottaleb MA, ODonnell JG, Stahl LL, Wathen JB, Snyder BD, Pitt JL, Perez-Hurtado P et al (2009) Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States