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These strategies will support a shift toward precision medicine approaches, ultimately improving treatment safety and patient quality of life

Abou-Seif MA, A Rabia, M Nasr, Clin Chem Lab Med , 2000

This rule, known as the 3-1-1 rule, has been around for a while

Koo and Duman, 2008), increased IL-1 production in the amygdala following chronic stress exposure (Porterfield et al., 2012), and TNF- involvement in anxiety and inflammatory pain (Chen et al., 2013)