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This includes three steps ( Figure S1A ): 62 definition of the extra-parasitic environment in the metabolic model, (2) identification of the minimal number of reactions required for growth, the resulting set of reactions is called minimal network (MiN), and (3) generation of an individual reaction by collapsing all the reactions present in the MiN into one lumped reaction

198 SIRT1 activation represents a potential strategy to disrupt the pathological feedback loop of microbiota imbalanceendotoxin entry into the liverinflammation activationliver damage, offering a novel entry point for systemic intervention in MASLD

As a key transcription factor in the antioxidant response, NRF2 upregulates GPX4 expression by binding to the antioxidant response element (ARE) in the promoter region of the GPX4 gene [96]

Cystine can enter the lysosomes via cystine-containing proteins or enter the cell via apical membrane transporters