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Individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2) should discuss this with their clinician before considering any GLP-1based therapy, and should be alert to symptoms such as a neck lump, hoarseness, or difficulty swallowing

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DSIP exposure correlated with decreased corticosterone levels, potentially indicating stress-mitigating effects via the opioidergic system