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J Pineal Res 32:179186 Gomez-Pinilla PJ, Camello-Almaraz C, Moreno R, Camello PJ, Pozo MJ (2006) Melatonin treatment reverts age-related changes in guinea pig gallbladder neuromuscular transmission and contractility

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Apoptosis 2017;22:101324

Unfortunately, the prognosis remains poor, with a median overall survival (mOS) of 20.9 months and a median progression-free survival (mPFS) of 6.7 months ( Here, we will discuss the previously explored repurposing efforts in the treatment of GB based on targeting two of the three most altered signal transduction pathways in GB: Receptor tyrosine kinase (RTK) and cyclin-dependent kinase (CDK)-retinoblastoma (Rb) ( Despite an increased understanding of GB tumor biology with discoveries of potential targets, the unique challenges posed by this aggressive tumor continue to thwart treatment benefits