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Cancer promotion concerns arise from IGF-1's well-established role in cellular proliferation, survival, and growth

Among the three methods mentioned, Hausdroff distance is a more reliable measure of dissimilarity in GSM models due to its interval-based representation (hence, can be used for FVA-predicted flux ranges), ability to incorporate uncertainty, and its sensitivity to the extreme values

Either or both of these things may lead them to discontinue the medication

Because KAT6A contains multiple functional domains, it is possible that ARTHS variants may result in a truncated protein that retains acetyltransferase activity but lacks proteinprotein interaction domains that regulate this activity