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The discovery of this new SKN-1 allele validates the screen and supports the previous finding that this phenotype is dependent on skn-1 (figure 1c,d)

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10.1128/MCB.22.13.4803-4814.2002 Goodman CA, Miu MH, Frey JW, Mabrey DM, Lincoln HC, Ge Y, Chen J, Hornberger TA: A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy