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Electrophysiological recordings demonstrate that Dihexa-treated neurons exhibit significantly increased frequency of miniature excitatory postsynaptic currents (mEPSCs), indicating enhanced synaptic transmission

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Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids