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Incorrect dosing may lead to insufficient results or adverse effects

doi: 10.1016/j.tcb.2021.06.008

That's because "vitamin B12 is naturally present in foods of animal origin, including fish, meat, poultry, eggs, and dairy products", explains the National Institutes of Health (NIH)

It is a useful reminder to consider vitamin B12 deficiency in people taking metformin who have megaloblastic anaemia, neuropathy or other symptoms suggestive of deficiency