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Studies have shown that patients with FM have higher levels of oxidative stress markers, such as MDA and protein carbonyls, compared to healthy individuals 75

RIF decreased hepatic and blood Mrp1 mRNA levels in the KO-resistant groups by 21.17- and 1.24-fold and increased those in the intestines and spleens by 2.50- and 3.57-fold (Supplementary Material Fig

The carboxylic group(s) of the drug is typically negatively charged and the drug therefore is trapped within the cell, where it is to exert its antioxidative properties

Crit Rev Toxicol 29:59124 Zimniak P, Nanduri B, Pikula S et al (1994) Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in positron 104 differ in enzymic properties