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The GHRH receptor is saturable and somatostatin still applies the brake

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On a previous paper using an inflammatory model we used 600 mg/kg and 300 mg/kg and demonstrated that doses of 300 mg/kg were adequate for neuroprotection 17

Here we used such iPSC-derived complex liver organoids to assess the specific impact of ALGS-causing mutations on parenchymal and non-parenchymal liver cells, their role on bile duct formation and survival, and the interactions between signaling pathways suspected to play a role in ALGS pathophysiology