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KTP is performed using a corneal refractive laser off-label, and uses a mineral-based pigment that is inert when inserted into the translucent cornea using a cannula

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Specifically, PCI34051 blocks the activation of TGF- and p-Smad, reducing the phosphorylation of STAT3 and -catenin in renal tubular cells, and reversing the increase in HDAC8 expression, the increased deacetylation levels of cortical protein and the expression of fibrosis markers (-SMA, collagen 1, and fibronectin) induced by UUO

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