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The decrease in Nrf2 first leads to an increase of unbound Keap1, due to the reduced complex formation with Nrf2 (Fig 3C

Das hat mehrere Vorteile: Die Wirkstoffe gelangen direkt zum Wirkort Durch Umgehung der Darm- und Leberpassage kommt es zu keinem Wirkverlust und daher kann die Konzentration der verabreichten Wirkstoffe sehr gering gehalten werden