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Interestingly, a recent study showed that despite the low plasma concentration of polyphenols, polyphenols were transported to the arterial intima at pH 7.4 in the form of bound lipoproteins, and polyphenol levels were significantly elevated in endothelial cells and macrophages (148)

Other integrins, such as v5 integrin, can be found in clathrin-containing adhesion complexes whereas 31, 61, and 41 integrins can be found in tetraspanin-enriched microdomains (Zuidema et al., 2020)

More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported (Mpakali et al., 2020)