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NSAIDs may increase the risk of a cardiovascular thrombotic event in patients with or without underlying heart disease or risk factors for heart disease

Bone health monitoring Rapid weight loss from any cause, including GLP-1 therapy, can accelerate bone density loss, particularly in postmenopausal women

In addition, it is one of a few antihyperglycemic agents associated with improvements in cardiovascular morbidity and mortality, which is a major cause of death in patients with type 2 diabetes