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CLSM images and quantitative analysis (Fig

The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

The involvement of microbes in NAD synthesis through enzymatic expression is complex, which is essential for NAD precursors supplementation to exert therapeutic functions [55]