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4 Astrocytes in the chronic phase 4.1 Post-stroke cognitive impairment Stroke increases the risk of cognitive impairment (Rost et al., 2022), representing a daunting long-term consequence for stroke survivors (McKevitt et al., 2011

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A double-blind randomized controlled trial demonstrated that adding memantine to conventional cinnarizine treatment significantly reduced tinnitus severity index scores compared to placebo, suggesting a beneficial effect (Pourayyoubi et al., 2025)

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Hypothyroidism can lower IGF-1 levels and contribute to symptoms similar to growth hormone deficiency

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